Left ventricular histological parameters and their correlation with calibrated integrated backscatter values in 29 men and 11 women with coronary artery disease
| Variable | Mean±SD or median (IQR) (n=40) | r | p Value |
|---|---|---|---|
| Total fibrosis (%) | 1.8 (1.2–2.6)* | −0.32† | 0.047† |
| Interstitial fibrosis (%) | 1.3 (0.9–1.7)* | −0.34† | 0.03† |
| Perivascular fibrosis ratio | 1.7 (1.1–2.3)* | −0.12† | 0.49† |
| Arterioles/mm2 myocardium area | 0.8±0.4 | −0.02 | 0.90 |
| Mean arteriolar diameter (μm) | 40±12 | −0.17 | 0.31 |
| Arteriolar wall area/circumference ratio (μm2/μm) | 5.5±1.7 | −0.07 | 0.66 |
| Cardiomyocyte width (μm) | 22±3 | −0.26 | 0.11 |
| Capillary length density (mm/mm3) | 1106±419 | 0.11 | 0.51 |
| Diffusion radius (μm) | 18±4 | −0.12 | 0.47 |
| Collagen I total fibrosis (%) | 5.0±3.9 | 0.06 | 0.74 |
| Collagen I interstitial fibrosis (%) | 2.4±2.8 | 0.08 | 0.61 |
| Collagen III total fibrosis (%) | 10.0±4.6 | −0.03 | 0.86 |
| Collagen III interstitial fibrosis (%) | 7.4±4.0 | −0.02 | 0.92 |
| Total collagen I/III ratio | 0.57±0.46 | 0.12 | 0.48 |
| Interstitial collagen I/III ratio | 0.35±0.27 | 0.11 | 0.51 |
| CML immunostaining arteriole media | 1.6±0.8 | 0.15 | 0.36 |
| CML immunostaining arteriole intima | 1.8±0.7 | 0.07 | 0.65 |
| RAGE immunostaining arteriole media | 0.6±0.7 | −0.14 | 0.41 |
| RAGE immunostaining arteriole intima | 1.6±0.8 | −0.11 | 0.49 |
| RAGE immunostaining capillaries | 1.3±1.0 | 0.07 | 0.68 |
*Median value and IQR given non-parametric distribution.
†Values derived from log-transformed data; n=40, except for perivascular fibrosis where n=38, and for capillary length density and diffusion radius where n=39; arteriolar wall area/circumference ratio was measured for arterioles with diameter (average of maximum and minimum diameter of each arteriole) of 20–80 μm.
CML, Nε-(carboxymethyl)lysine; RAGE, receptor for advanced glycation end products.