Discrimination of the prediction models derived from multivariate hazard models excluding patients with normal or low ALT
| Models | AUC c-statistic | SE* | 95% CI |
|---|---|---|---|
| AST/ALT excluded | |||
| Framingham risk factors | 0.66 | 0.013 | 0.64 to 0.69 |
| QRISK2 risk factors | 0.68 | 0.014 | 0.65 to 0.71 |
| AST/ALT ratio included | |||
| Framingham risk factors+AST/ALT ratio | 0.71 | 0.013 | 0.68 to 0.73 |
| QRISK2 Risk factors+AST/ALT ratio | 0.72 | 0.013 | 0.69 to 0.74 |
Higher area under receiver operating curve (AUC c-statistic) shows better model performance.
*SE estimated by jack-knife procedure.
ALT, alanine transaminase; AST, aspartate transaminase.