Discrimination of the prediction models derived from multivariate hazard models
| Models | AUC c-statistic | SE* | 95% CI |
|---|---|---|---|
| AST/ALT excluded | |||
| Model 1a: Age+gender | 0.68 | 0.009 | 0.66 to 0.70 |
| Model 2a: Framingham risk factors | 0.72 | 0.009 | 0.70 to 0.74 |
| Model 3a: QRISK2 risk factors | 0.73 | 0.008 | 0.71 to 0.74 |
| AST/ALT ratio included | |||
| Model 1b: Age+gender+AST/ALT ratio | 0.69 | 0.009 | 0.67 to 0.71 |
| Model 2b: Framingham risk factors+AST/ALT ratio | 0.72 | 0.009 | 0.71 to 0.74 |
| Model 3b: QRISK2 risk factors+AST/ALT ratio | 0.73 | 0.008 | 0.71 to 0.74 |
| Comparator models | |||
| Model 4: Age+gender+systolic blood pressure | 0.69 | 0.009 | 0.67 to 0.71 |
| Model 5: Age+gender+TC/HDL ratio | 0.69 | 0.009 | 0.67 to 0.71 |
Higher area under receiver operating curve (AUC c-statistic) shows better model performance.
SE estimated by jack-knife procedure.
ALT, alanine transaminase; AST, aspartate transaminase; HDL, high-density lipoprotein; TC, total cholesterol.