Summary of human studies that support the sequence of events in the ischaemic cascade
| Study | Sample size | Ischaemic state | Blinded study |
|---|---|---|---|
| Sestito et al30 | 30 | Dipyridamole stress echocardiography | Not reported |
| Kyrzopoulos et al31 | 148 | Dobutamine stress echocardiography | Not reported |
| Heller et al29 | 19 | Exercise testing | Yes |
| Williams et al28 | 104 | Bicycle ergometer stress echocardiography | Not reported |
| Nixdorff et al27 | 16 | Bicycle ergometer stress echocardiography | Yes |
| Hyodo et al26 | 53 | Dobutamine stress echocardiography | Yes |
| Alam et al10 | 12 | Coronary artery occlusion | No |
| Hauser et al11 | 18 | Coronary artery occlusion | Not reported |
| McLaurin et al13 | 15 | Rapid atrial pacing | Not reported |
| Iskandrian et al14 | 12 | Rapid atrial pacing | Not reported |
| Aroesty et al15 | 22 | Rapid atrial pacing | Not reported |
| Reduto et al17 | 68 | Exercise testing | Not reported |
| Berger et al 197919 | 73 | Exercise testing | Not reported |
| Distante et al20 | 12 | Patients with Prinzmetal's angina (spontaneous angina, or induced by ergonovine) | Not reported |