Included studies that measured troponins
| Author | Date | Study size | Method | Outcome | OR/HR |
|---|---|---|---|---|---|
| Baillard et al13 | 2003 | n=71 | Prospective cohort study | Elevated cardiac troponin I is a predictor of in-hospital death in patients admitted for AECOPD | ORa 6.52; 95% CI 1.23 to 34.47 |
| Harvey et al12 | 2004 | n=188 | Retrospective study | Significant association between raised troponin levels and increased length of hospital stay (p<0.001) reported | |
| Abroug et al8 | 2006 | n=148 | Prospective study | Useful in excluding AECOPD associated with LVD | A cut-off of 1000 pg/mL was accurate to rule out left heart involvement in AECOPD (sensitivity, 94%; negative predictive value, 94%; negative likelihood ratio, 0.08). A cut-off of 2500 pg/mL had the best operating characteristics to rule in the diagnosis (positive likelihood ratio, 5.16) |
| Brekke et al14 | 2008 | n=396 | Prospective cohort study—cross sectional. Used logistic regression to identify factors in AECOPD associated with an increased cTnT | Elevated cTnT is significantly associated with increased all-cause mortality in the observation period (median=1.9 years) | HR 1.61 (1.13 to 2.29) |
| Fruchter et al15 | 2009 | n=182 | Retrospective study | Out of hospital mortality. Follow-up from 3–83 months, mean of 35 | HR=1.0653, 95% CI 1.0753 to 2.2512 |
| Martins et al16 | 2009 | n=173 | Retrospective cohort study | In-hospital mortality, 18-month survival | Only p values available. Both peak and baseline cardiac troponin I predict overall 18-month survival (p=0.007 and p=0.012, respectively) |
| Høiseth et al17 | 2011 | n=99 | Prospective cohort study | Elevated cTnT during AECOPD is associated with increased mortality over a median follow-up time of 1.9 years | Adjusting for relevant covariables using an extended Cox regression analysis, the HRs (95% CI) for death were 4.5 (1.2 to 16) and 8.9 (2.4 to 32) among patients having hs-cTnT 14.0–39.9 and ≥40 ng/L, respectively, compared with patients with hs-cTnT <14.0 ng/L |
| Chang et al6 | 2011 | n=244 | Prospective cohort study | Elevated troponin T predicts 30-day mortality (p<0.001) but does not predict deaths between 30 days and 1-year follow-up (p=0.63) | OR 6.3, 95% CI 2.4 to 16.5, p<0.001 |
| Høiseth et al11 18 | 2012 | n=97 | Prospective cohort study | survival status | Survival status was significantly associated with hs-cTnT, with a relative value of 1.58 (95% CI 1.11 to 2.23) |
| Marcun et al1 | 2012 | n=127 | Prospective observational study | Raised troponin T levels at discharge predict recurrent hospitalisation within the following 6 months | HR=2.89, 95% CI 1.13 to 7.36 |
AECOPD, acute exacerbations of chronic obstructive pulmonary disease; cTnT, cardiac troponin T; LVD, left ventricular dysfunction; ORa, adjusted OR.