Outcome data from included trials of diet and events for intervention (Int) and control (Ctrl) groups
| Intervention | Outcomes | ||||||
|---|---|---|---|---|---|---|---|
| Study | Participants Int/Ctrl | Type | Years | Diet | All deaths Int/Ctrl | CHD deaths Int/Ctrl | Change in mean serum cholesterol Int/Ctrl (%) |
| Rose Corn oil | 28/26 (under 70) | S | 2 | 64 g corn oil/day | 5/1 | 5/1 deaths | −7.6/−1.2 |
| Rose Olive oil (1965)14 | 26/26 (under 70) | S | 2 | 58 g olive oil/day | 3/1 | 3/1 deaths | −0.4/−1.2 |
| Research Committee Low-fat Diet (1965)15 | 123/129 (under 65) | S | 3 | 40 g fat/day | 20/24 | 17/20 deaths | −16.9/−12.4 |
| MRC Soybean Oil (1968)16 | 199/194 (under 60) | S | 3.4 | 85 g soya-bean oil/day+many banned foods | 28/31 | 27/25 deaths | −16.9/−5.9 |
| LA Veterans Study (1969)17 | 424/422 (age 55+) | P/S | 8 | 40% cals from fat, 2/3 fat from veg oils | 174/177 | 41/50 deaths | −18.0/−14.1 |
| Oslo Diet Heart Study (1970)18 19 | 206/206 (30–64 year) | S | 11 | 40% cals from fat, 72% fat from soya-bean oil | 101/108 | 79/94 deaths | −17.6/−3.7 (5 year data) |
| The Sydney Diet Heart Study (1978)20 | 221/237 (30–59 year) | S | 5 | 10% sat/15% poly vs 14% sat/9% poly | 39/28 | 35/25 deaths | −11.0/−7.1 |
| TOTAL | 1227/1240 | 370/370 | 207/216 | Mean −12.6/−6.5 S.D. 6.7/5.1 | |||
P, primary study; S, secondary study.