Estimates of the associations between treadmill exercise test responses and genetic polymorphism in the study population
| Interaction p Value | Estimate | p Value | Estimate | p Value | |
|---|---|---|---|---|---|
| Exercise capacity | |||||
| ADRA1A rs1048101 (Cys/Cys vs Cys/Arg) | 0.220 | 0.45 | 0.070 | – | – |
| ADRA1A rs1048101 (Arg/Arg vs Cys/Arg) | 0.327 | 0.18 | 0.416 | – | – |
| ADRA2A rs553668 (CC vs CT) | 0.278 | 0.01 | 0.960 | – | – |
| ADRA2A rs553668 (TT vs CT) | 0.838 | 0.21 | 0.683 | – | – |
| ADRA2B rs28365031 (DD vs ID) | 0.709 | −0.28 | 0.436 | – | – |
| ADRA2B rs28365031 (II vs ID) | 0.127 | −0.23* | 0.415* | 0.33† | 0.302† |
| eNOS rs2070744 (TT vs TC) | 0.085 | 2.14* | 0.010* | 0.34† | 0.733† |
| eNOS rs2070744 (CC vs TC) | 0.715 | 0.78 | 0.390 | − | − |
| eNOS rs1799983 (Glu/Glu vs Glu/Asp) | 0.539 | −0.47 | 0.038 | – | – |
| eNOS rs1799983 (Asp/Asp vs Glu/Asp) | 0.876 | −0.81 | 0.024 | – | – |
| BK2R rs5810761 (DD vs ID) | 0.998 | −0.40 | 0.129 | – | – |
| BK2R rs5810761 (II vs ID) | 0.292 | −0.15 | 0.497 | – | – |
| Exercise systolic blood pressure | |||||
| ADRA1A rs1048101 (Cys/Cys vs Cys/Arg) | 0.116 | 1.76* | 0.538* | 8.13† | 0.008† |
| ADRA1A rs1048101 (Arg/Arg vs Cys/Arg) | 0.714 | −1.31 | 0.503 | – | – |
| ADRA2A rs553668 (CC vs CT) | 0.008 | −6.41* | 0.008* | 3.73† | 0.140† |
| ADRA2A rs553668 (TT vs CT) | 0.444 | 1.97 | 0.657 | – | – |
| ADRA2B rs28365031 (DD vs ID) | 0.128 | −8.86* | 0.022* | −0.06† | 0.990† |
| ADRA2B rs28365031 (II vs ID) | 0.092 | −2.90* | 0.280* | 3.91† | 0.220† |
| eNOS rs2070744 (TT vs TC) | 0.562 | −2.99 | 0.121 | – | – |
| eNOS rs2070744 (CC vs TC) | 0.621 | −5.42 | 0.072 | – | – |
| eNOS rs1799983 (Glu/Glu vs Glu/Asp) | 0.956 | −0.29 | 0.880 | – | – |
| eNOS rs1799983 (Asp/Asp vs Glu/Asp) | 0.101 | 5.21* | 0.246* | −6.37† | 0.158† |
| BK2R rs5810761 (DD vs ID) | 0.065 | 6.02* | 0.522* | 29.06† | 0.008† |
| BK2R rs5810761 (II vs ID) | 0.451 | 8.40 | 0.200 | – | – |
| Exercise diastolic blood pressure | |||||
| ADRA1A rs1048101 (Cys/Cys vs Cys/Arg) | 0.946 | 0.23 | 0.817 | – | – |
| ADRA1A rs1048101 (Arg/Arg vs Cys/Arg) | 0.129 | 1.22* | 0.301* | −0.99† | 0.429† |
| ADRA2A rs553668 (CC vs CT) | 0.851 | −1.09 | 0.168 | – | – |
| ADRA2A rs553668 (TT vs CT) | 0.032 | 12.74* | 0.002* | 6.82† | 0.071† |
| ADRA2B rs28365031 (DD vs ID) | 0.599 | −2.12 | 0.114 | – | – |
| ADRA2B rs28365031 (II vs ID) | 0.641 | −0.79 | 0.382 | – | – |
| eNOS rs2070744 (TT vs TC) | 0.565 | 1.19 | 0.172 | – | – |
| eNOS rs2070744 (CC vs TC) | 0.786 | −0.24 | 0.861 | – | – |
| eNOS rs1799983 (Glu/Glu vs Glu/Asp) | 0.028 | −8.35* | 0.015* | −2.12† | 0.572† |
| eNOS rs1799983 (Asp/Asp vs Glu/Asp) | 0.850 | 0.28 | 0.848 | – | – |
| BK2R rs5810761 (DD vs ID) | 0.625 | 0.52 | 0.608 | – | – |
| BK2R rs5810761 (II vs ID) | 0.178 | −0.07 | 0.933 | – | – |
When interactions p value <0.15, complementary analyses were performed to investigate associations between the polymorphisms and dependent variables for each gender.
*For women.
†For men.
ADRA, α-adrenergic receptors; eNOS, endothelial nitric synthase.