Inflammatory response following diagnostic angiography and percutaneous coronary angiography
| 0 h† | 6 h | 24 h | 48 h | 72 h | 168 h | ANOVA | |
|---|---|---|---|---|---|---|---|
| Angiography | |||||||
| Leucocytes (×109/L) | 6.7±0.5 | 6.9±0.7 | 7.1±0.5 | 6.9±0.6 | 7.2±0.6 | 6.3±0.7 | 0.24 |
| Neutrophils (×109/L) | 4.1±0.4 | 4.1±0.4 | 4.4±0.4 | 4.1±0.3 | 4.4±0.4 | 4.1±0.4 | 0.57 |
| Lymphocytes (×109/L) | 1.7±0.2 | 2.0±0.3 | 1.8±0.2 | 1.9±0.3 | 1.9±0.3 | 1.7±0.3 | 0.07 |
| Monocytes (×109/L) | 0.56±0.03 | 0.59±0.06 | 0.59±0.05 | 0.58±0.05 | 0.58±0.04 | 0.56±0.05 | 0.93 |
| CRP (mg/L) | 1.2 (0.6–3.3) | 1.3 (0.6–2.9) | 1.5 (0.8–2.8) | 1.4 (0.7–4.0) | – | 1.6 (0.8–4.1) | 0.97 |
| VEGF-A (pg/L) | 76±13 | 54±10 | 69±9 | 68±8 | – | 79±13 | 0.16 |
| PCI | |||||||
| Leucocytes (×109/L) | 6.2±0.2 | 6.8±0.3 | 7.2±0.3* | 7.0±0.4* | 6.7±0.3 | 6.5±0.3 | 0.04 |
| Neutrophils (×109/L) | 3.8±0.2 | 4.2±0.3 | 4.7±0.2* | 4.3±0.3 | 4.0±0.2 | 3.8±0.3 | 0.04 |
| Lymphocytes (×109/L) | 1.8±0.1 | 1.9±0.1 | 1.7±0.2 | 1.9±0.1 | 1.9±0.1 | 1.8±0.1 | 0.41 |
| Monocytes (×109/L) | 0.49±0.02 | 0.54±0.04 | 0.54±0.03 | 0.54±0.03 | 0.51±0.03 | 0.48±0.04 | 0.14 |
| CRP (mg/L) | 1.0 (0.6–2.3) | 1.3 (0.8–2.4) | 2.6 (1.0–4.5)* | 4.0 (1.3–8.3)** | – | 2.0 (0.9–3.6) | 0.002 |
| VEGF-A (pg/L) | 72±8 | 57±5 | 57±5 | 56±5 | – | 50±5 | 0.16 |
Data are expressed as median and IQR or mean±SE of the mean. Statistical analyses are performed using repeated measures ANOVA (Friedman's test for non-parametric data) and Bonferroni's or Dunn's Multiple comparison test, where appropriate. Comparisons between time points are made using a paired Student's t test or Wilcoxon test, where appropriate.
*p<0.05 and **p=0.001 for preprocedure versus time point.
†Between group baseline comparison was made for each variable using a Mann-Whitney or unpaired Student t test, where appropriate.
ANOVA, analysis of variance; CRP, C reactive protein; PCI, percutaneous coronary intervention; VEGF-A, vascular endothelial growth factor-A.