Multivariable associations with cardiac mortality using baseline characteristics
| Age-adjusted | Fully adjusted* | ||||
|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | p Value | |
| Peak flow rate (L/min)† | |||||
| <430 | 1.54 | 1.07 to 2.21 | 1.53 | 1.04 to 2.25 | 0.025‡ |
| 430–<490 | 1.40 | 0.98 to 2.00 | 1.43 | 0.99 to 2.08 | |
| 490–<550 | 1.30 | 0.93 to 1.81 | 1.31 | 0.93 to 1.86 | |
| ≥550 | 1 | – | 1 | – | |
| Systolic blood pressure | |||||
| Per 10 mm Hg increase | 1.18 | 1.12 to 1.24 | 1.13 | 1.07 to 1.19 | <0.0001 |
| Body mass index | |||||
| Per kg/m2 increase | 1.11 | 1.06 to 1.15 | 1.09 | 1.04 to 1.14 | 0.0002 |
| Smoking status | |||||
| Non-smoker | 1 | – | 1 | – | 0.015‡ |
| Ex-smoker | 1.24 | 0.84 to 1.85 | 1.04 | 0.70 to 1.56 | |
| Current smoker | 1.61 | 1.13 to 2.31 | 1.51 | 1.02 to 2.24 | |
| Previous angina | |||||
| No | 1 | – | 1 | – | 0.010 |
| Yes | 2.11 | 1.36 to 3.27 | 1.83 | 1.16 to 2.90 | |
| Cholesterol | |||||
| Per mmol/L increase | 1.29 | 1.17 to 1.43 | 1.18 | 1.05 to 1.33 | 0.005 |
| Fibrinogen (g/L) | |||||
| ≤3.5 | 1 | – | 1 | – | 0.001‡ |
| >3.5–4 | 1.78 | 1.29 to 2.46 | 1.44 | 1.03 to 2.03 | |
| >4 | 1.91 | 1.25 to 2.89 | 1.91 | 1.22 to 2.98 | |
| Factor VII (% of standard) | |||||
| Per 10 unit increase | 1.10 | 1.05 to 1.14 | 1.05 | 1.00 to 1.10 | 0.058 |
| ECG | |||||
| Low risk | 1 | – | 1 | – | 0.021 |
| High risk | 1.74 | 1.23 to 2.45 | 1.52 | 1.07 to 2.19 | |
*Also adjusted for age, triglycerides, platelets, white blood cell count, red blood cell count, haemoglobin, packed cell volume, alcohol use, social class, factor V and factor VIII.
†Unadjusted HRs for peak flow rate are 3.33 (<430), 2.51 (430–<490) and 1.70 (490–<550) compared with ≥550 L/min.
‡Trend test across groups.