Table 4

Inclusion criteria and study quality of included cardiovascular outcomes trials

TrialCohortQuality of study*
ABCD46Patients with long or multivessel disease undergoing PCI++±
ACCEL-AMI29Patients with ACS undergoing PCI+++
ACCEL-LOADING-ACS30Patients with non-ST-elevation MI undergoing PCI±±±
ACCEL-RESISTANCE33Patients with high on-treatment platelet reactivity undergoing PCI++±
Ahn et al47Patient with ACS undergoing PCI±±+
Chen et al48Patients with ACS undergoing PCI±++
CIDES49Patients with diabetes undergoing PCI±±±
CILON-T34Patients with angina undergoing PCI++±
CLEAR50Patients with stable angina undergoing PCI±±±
CREST51Patients with ACS/known stenosis undergoing PCI+++
DECLARE-DIABETES52Patients with ACS and diabetes undergoing PCI+±±
DECLARE-LONG54Patients with ACS and stenosis of long (>25 mm) lesions undergoing PCI+±±
DECLARE-LONG II55Patients with ACS/known stenosis of long (>25 mm) lesions undergoing PCI+++
Gao et al35Obese patients undergoing PCI±±±
Guan et al36Patients with ACS and high on-treatment platelet reactivity undergoing PCI±±±
Han et al56Patients with ACS undergoing PCI++±
Han et al57Patients with ACS undergoing PCI±±±
HOST-ASSURE37All-comer patients undergoing PCI±±+
Hu et al58Patients with ACS undergoing PCI±±±
Jin et al39Patients undergoing PCI±++
Kim et al59Patients with ACS/known stenosis undergoing PCI±±±
Kim et al41Patients with ST-elevation MI undergoing PCI±±±
Kum et al42Patients with ACS/known stenosis undergoing PCI±±±
Lee et al60Patients undergoing elective PCI+±±
LONG-DES-II61Patients with stenosis of long lesions undergoing PCI++±
Lu et al70Patients undergoing PCI±±+
Lu et al64Patients with ADP-induced platelet inhibition rates <30% undergoing PCI+±±
Min et al10Patients with ACS/known stenosis undergoing elective PCI±+±
OPTIMUS-26Patients with diabetes undergone PCI+++
Shen et al65Patients with ACS undergoing PCI±±±
Suh et al66Patients with diabetes and chronic total occlusion undergoing PCI±±±
Wang et al67Patients with small vessel stenosis undergoing PCI±±±
Wang et al68Patients with non-ST-elevation MI undergoing PCI±±±
Zang et al69Patients with ACS undergoing PCI±±±
  • *Represents risk of bias based on: sequence generation of allocation; allocation concealment and blinding. ‘+’ represents low bias risk, ‘−’ high bias risk and ‘±’ unclear bias risk.

  • ABCD, Evaluating Additional Benefit of Cilostazol to Dual Antiplatelet Therapy in Patients with Long or Multivessel Coronary Artery Disease underwent Biolimus-Eluting Stent Implantation; ACS, acute coronary syndrome; AMI, acute myocardial infarction; BES, biolimus-eluting stent; BMS, bare metal stent; CIDES, comparison of cilostazol versus clopidogrel after drug-eluting stenting in diabetic patients; CILON-T, Influence of Cilostazol-based Triple Antiplatelet Therapy on Ischaemic Complication After Drug-eluting Stent Implantation; CLEAR, The Cilostazol Administration Before Percutaneous Coronary Intervention for Reduction of Periprocedural Myonecrosis Trial; CREST, Coronary Stent Restenosis in Patients Treated with Cilostazol; DECLARE-LONG II: Triple Antiplatelet Therapy With Dual Antiplatelet Therapy to Reduce Restenosis After Drug-Eluting Stent Implantation in Long Coronary Lesions; DECLARE-DIABETES, A Randomised Comparison of Triple Antiplatelet Therapy with Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Diabetic Patients; DECLARE-LONG, Drug-Eluting Stenting Followed by Cilostazol Treatment Reduces Late Restenosis in Patients with Long Coronary Lesions; DES, drug-eluting stent; DM, diabetes mellitus; EES, everolimus-eluting stent; EES-PtCr, everolimus-eluting platinum-chromium alloy stent; LONG-DES, Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent for Patients With Long Coronary Artery Disease; OPTIMUS-2, Impact of Cilostazol on Platelet Function Profiles in Patients with Diabetes Mellitus and Coronary Artery Disease on Dual Antiplatelet Therapy; PES, Paclitaxel-eluting stent; SES, Sirolimus-eluting stent; ZES, Zotarolimus-eluting stent; ZES-R, Zotarolimus-eluting Resolute stent.

  • Other trial expansions as in tables 1 and 2.