Summary of risk of mortality and MACEs among patients with and without major bleed after percutaneous coronary intervention with different definitions of bleeding
| Mortality | MACEs | ||||||
|---|---|---|---|---|---|---|---|
| Definition of major bleed | OR | I2 (%) | Number of participants | Definition | OR | I2 | Number of participants |
| BARC23 38 48 | 5.40 (1.74 to 16.74) | 88 | 14 550 | BARC | NA | NA | NA |
| CRUSADE33 35 45 | 3.69 (1.68 to 8.12) | 85 | 14 055 | CRUSADE | NA | NA | NA |
| GUSTO24 40 46 | 4.30 (3.76 to 4.92) | 0 | 27 222 | GUSTO24 | 4.37 (3.78 to 5.07) | NA | 26 452 |
| HORIZON-AMI47 54 | 1.51 (1.11 to 2.05) | 12 | 13 233 | HORIZON-AMI | NA | NA | NA |
| REPLACE17 23 34 | 6.69 (2.26 to 19.81) | 84 | 17 996 | REPLACE | NA | NA | NA |
| STEEPLE18 25 37 43 56 | 6.59 (3.89 to 11.16) | 53 | 23 107 | STEEPLE43 | 3.19 (1.89 to 5.37) | NA | 3170 |
| TIMI2 8 11 19 20 21 22 42 44 49 50 52 53 55 | 5.15 (4.01 to 6.61) | 69 | 69 449 | TIMI21 | 2.41 (1.42 to 4.35) | NA | 1348 |
| Other14 27 28 32 36 39 51 | 3.34 (2.59 to 4.32) | 76 | 346 670 | Other36 | 3.99 (3.3 to 4.82) | NA | 19 622 |
MACEs, major adverse cardiovascular events; NA, not applicable.