Estimates of the longitudinal analyses mean the absolute baseline to follow-up difference of echocardiographic parameters.

Adjusted for arterial mean pressure, body surface area, age, medication, HbA1c, LDL and creatinine clearance.

*(grey-shaded line)=results from mixed models estimating the association of inflammation parameter across all six echocardiographic parameters in the cross-sectional, and longitudinal analyses, respectively. Estimates were standardised (mean=0, SD=1).

EF, ejection fraction; HbA1c, glycated haemoglobin; IL-6, interleukin 6; IVSD, interventricle septum diameter; LADS, left atrial diastolic diameter; LVDD, left ventricular end-diastolic dimension; LDL, low-density lipoprotein; LVM, left ventricular mass; PWD, posterior wall dimension; sTNF-R1, soluble tumour necrosis factor-α receptor 1.