Baseline characteristics of 65 patients having elevated hs-cTnT concentrations (≥14 ng/L) on admission for AECOPD
| hs-cTnT pattern | |||
|---|---|---|---|
| Variable | Stable (n=12) | Dynamic (n=53) | p Value |
| Demographics | |||
| Age, years (SD) | 78.9 (6.5) | 70.3 (8.7) | 0.002 |
| Female, n (%) | 4 (33%) | 24 (45%) | 0.531 |
| Medical history | |||
| Coronary artery disease, n (%) | 5 (42%) | 9 (17%) | 0.060 |
| Left heart failure, n (%) | 3 (25%) | 5 (9.4%) | 0.158 |
| Right heart failure, n (%) | 0 | 3 (5.7%) | 0.399 |
| FEV1, L (SD)* | 0.88 (0.39) | 0.91 (0.47) | 0.845 |
| FEV1/FVC ratio, % (SD)* | 44 (11) | 46 (14) | 0.719 |
| Current smokers, n (%) | 3 (25%) | 19 (36%) | 0.737 |
| Prior smokers, n (%) | 8 (67%) | 27 (51%) | 0.359 |
| Never smokers, n (%) | 0 | 0 | – |
| Laboratory tests | |||
| Hb, g/dL, mean (SD) | 12.9 (1.5) | 14.2 (1.6) | 0.016 |
| Creatinine, µg/L, mean (SD) | 82 (36) | 77 (41) | 0.493 |
| eGFR, mL/min/1.73 m2, mean (SD) | 85 (38) | 93 (38) | 0.510 |
| First hs-cTnT, ng/L, median (IQR) | 38.2 (28.0–53.7) | 31.2 (17.8–60.3) | 0.577 |
| Highest hs-cTnT, ng/L, median (IQR) | 38.9 (28.8–53.7) | 39.4 (21.9–71.1) | 0.987 |
| NT-proBNP tertile | 0.073 | ||
| 1 (<283 pg/mL), n (%) | 1 (8.3%) | 20 (38%) | |
| 2 (283–1181 pg/mL), n (%) | 4 (33%) | 18 (34%) | |
| 3 (≥1181 pg/mL), n (%) | 8 (58%) | 15 (28%) | |
| ECG analysis | |||
| Current iscahemia, n (%) | 5 (42%) | 19 (36%) | 0.706 |
| Prior myocardial infarction, n (%) | 3 (25%) | 7 (13%) | 0.376 |
| Atrial fibrillation, n (%) | 2 (17%) | 3 (5.7%) | 0.227 |
| P pulmonale | 4 (33%) | 15 (28%) | 0.735 |
| Right ventricular hypertrophy | 1 (8.3%) | 8 (15%) | 0.999 |
The table includes variables that differed with a p value <0.20. Gender, lung and kidney function, smoking status, chest pain and ECG analyses are also included for characterisation of the cohort.
*Spirometry missing in seven patients, n=10 and 48.
AECOPD, acute exacerbation of chronic obstructive pulmonary disease; BNP, B-type natriuretic peptide; eGFR, epidermal growth factor receptor; FEV, forced expiratory volume in 1 s; FVC, forced vital capacity; Hb, haemoglobin.