RT Journal Article
SR Electronic
T1 Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e000709
DO 10.1136/openhrt-2017-000709
VO 5
IS 1
A1 Sara Di Marino
A1 Nicola Viceconte
A1 Angelo Lembo
A1 Vincenzo Summa
A1 Gaetano Tanzilli
A1 Valeria Raparelli
A1 Giovanni Truscelli
A1 Enrico Mangieri
A1 Carlo Gaudio
A1 Daniel Oscar Cicero
YR 2018
UL http://openheart.bmj.com/content/5/1/e000709.abstract
AB Objective Balloon-induced transient coronary ischaemia represents a model of myocardial ischaemia and reperfusion. We are interested in the very early systemic metabolic response to this event.Methods Blood samples of patients with stable angina (SA) were collected before and after coronary angioplasty. Serum metabolic profiles were obtained using nuclear magnetic resonance spectroscopy. Univariate and multivariate analyses were used to investigate changes in metabolite concentrations.Results Thirty-four consecutive patients with SA, undergoing elective coronary angioplasty at Policlinico Umberto I of Rome, were included in this study. Changes in metabolites concentration induced by balloon occlusion in venous and arterial sera were detected. In both serum types, a significant increase in ketone bodies, 2-hydroxybutyrate, glutamine and O-acetylcarnitine concentration is observed, while alanine, lactate, phenylalanine and tyrosine decreased after intervention. Most significant metabolic changes were detected in arterial serum.Conclusions Our study points out two main global metabolic changes in peripheral blood after balloon-induced coronary ischaemia: ketone bodies increase and lactate decrease. Both could be related to compensation mechanisms finalised to fulfil heart’s needs after short period of myocardial ischaemia and probably after reperfusion.