PT  - JOURNAL ARTICLE
AU  - Baris Gencer
AU  - Nicolas Rodondi
AU  - Reto Auer
AU  - David Nanchen
AU  - Lorenz Räber
AU  - Roland Klingenberg
AU  - Mark Pletscher
AU  - Peter Jüni
AU  - Stephan Windecker
AU  - Christian M Matter
AU  - Thomas F Lüscher
AU  - François Mach
AU  - Thomas V Perneger
AU  - François R Girardin
TI  - Health utility indexes in patients with acute coronary syndromes
AID  - 10.1136/openhrt-2016-000419
DP  - 2016 May 01
TA  - Open Heart
PG  - e000419
VI  - 3
IP  - 1
4099  - http://openheart.bmj.com/content/3/1/e000419.short
4100  - http://openheart.bmj.com/content/3/1/e000419.full
SO  - Open Heart2016 May 01; 3
AB  - Background Acute coronary syndromes (ACS) have been associated with lower health utilities (HUs) compared with the general population. Given the prognostic improvements after ACS with the implementation of coronary angiography (eg, percutaneous coronary intervention (PCI)), contemporary HU values derived from patient-reported outcomes are needed.Methods We analysed data of 1882 patients with ACS 1 year after coronary angiography in a Swiss prospective cohort. We used the EuroQol five-dimensional questionnaire (EQ-5D) and visual analogue scale (VAS) to derive HU indexes. We estimated the effects of clinical factors on HU using a linear regression model and compared the observed HU with the average values of individuals of the same sex and age in the general population.Results Mean EQ-5D HU 1-year after coronary angiography for ACS was 0.82 (±0.16) and mean VAS was 0.77 (±0.18); 40.9% of participants exhibited the highest utility values. Compared with population controls, the mean EQ-5D HU was similar (expected mean 0.82, p=0.58) in patients with ACS, but the mean VAS was slightly lower (expected mean 0.79, p<0.001). Patients with ACS who are younger than 60 years had lower HU than the general population (<0.001). In patients with ACS, significant differences were found according to the gender, education and employment status, diabetes, obesity, heart failure, recurrent ischaemic or incident bleeding event and participation in cardiac rehabilitation (p<0.01).Conclusions At 1 year, patients with ACS with coronary angiography had HU indexes similar to a control population. Subgroup analyses based on patients' characteristics and further disease-specific instruments could provide better sensitivity for detecting smaller variations in health-related quality of life.