Elsevier

Metabolism

Volume 30, Issue 5, May 1981, Pages 421-424
Metabolism

Preliminary report
Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

https://doi.org/10.1016/0026-0495(81)90173-6Get rights and content

Abstract

In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.

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Supported in part by USPHS Grants HL 24084 and AM 20378.

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