You are here

  • Home
  • Archive
  • Volume 4, Issue 2
  • Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients

Article Text

Article menu

Download PDFPDF

Heart failure and cardiomyopathies
Original research article
Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients
  1. Marianne Yardley1,2,3,
  2. Thor Ueland2,4,5,6,
  3. Pål Aukrust2,4,5,6,7,
  4. Annika Michelsen2,4,
  5. Elisabeth Bjørkelund1,
  6. Lars Gullestad1,2,8 and
  7. Kari Nytrøen1,2
  1. 1 Department of Cardiology, Oslo University Hospital, Oslo, Norway
  2. 2 Faculty of Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
  3. 3 The Norwegian Health Association, Oslo, Norway
  4. 4 Research Institute for Internal Medicine, Oslo University Hospital, Oslo, Norway
  5. 5 K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway
  6. 6 K.G. Jebsen Thrombosis and Expertise Center (TREC), The Arctic University of Norway, Tromsø, Norway
  7. 7 Section of Clinical Immunology and Infectious Disease, Oslo Universitetssykehus, Oslo, Norway
  8. 8 Center for Heart Failure Research, University of Oslo, Oslo, Norway
  1. Correspondence to Ms Marianne Yardley; marianneyardley{at}gmail.com

Abstract

Background The present study explored and compared the immediate responses in markers of inflammation and angiogenesis in maintenance heart transplant (HTx) recipients before, during and after sessions of high-intensity interval training (HIT) versus moderate-intensity continuous training (MICT). The study aimed to explain some of the trigger mechanisms behind HIT in HTx recipients.

Methods This cross-over study included 14 HTx patients (mean±SD age: 53±13 years; time since HTx, 3±2 years). All participants underwent baseline blood samples and a cardiopulmonary exercise test during their first visit. The next two visits included one HIT session and one MICT session, in randomised order. Blood samples were taken during and after each exercise session. Myokines and inflammatory markers related to vascular inflammation, blood-platelet activation and modulation of angiogenesis were analysed.

Results The main findings in this study were (1) exercise, regardless of intensity, induced a significant immediate response in several vascular, angiogenetic and in particular platelet-derived inflammatory mediators in HTx recipients. (2) HIT showed trends to induce an increased response in von Willebrand factor, vascular endothelial growth factor-1 and angiopoetin-2, and a decreased response in growth differentiation factor-15, compared with MICT.

Conclusions This pattern and in particular the trend towards an increased angiogenetic mediator response could contribute to the beneficial effects of HIT in HTx recipients.

Trial registration number NCT02602834.

  • heart transplant
  • inflammation
  • exercise therapy for cardiac transplant recipients
  • vascular endothelial growht factor
  • high intensity interval training[title]

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/openhrt-2017-000635

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors MY (corresponding author) was the main researcher of this cross-over study and contributed to the design of the study, inclusion of patients, data collection with the exercise sessions and physical tests, data analysis and drafting the article. TU evaluated the markers of inflammation and angiogenesis that were analysed, contributed with the statistics and the data interpretation, tables and figures, and critically revised the manuscript. AM contributed to the analysis of the inflammatory markers from all blood samples and critically revised the manuscript. PA contributed with the data interpretation and critically revised the manuscript. EB contributed with the coordination of the study participants and drawing blood samples at study visits, and critically revised the manuscript. LG contributed to the design of the study and data interpretation, and critically revised the manuscript. KN contributed to the design and the data interpretation, and drafted and critically revised the manuscript.

    • Funding This work was funded by student research grants from the Norwegian Health Association and the South-East Regional Health Authority in Norway.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval South-East Regional Committee for Medical and Health Research Ethics in Norway (approval no. 2015/97).

    • Provenance and peer review Not commissioned; externally peer reviewed.