Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: an updated meta-analysis

Rhanderson N Cardoso; Alexandre M Benjo; James J DiNicolantonio; Daniel C Garcia; Francisco Y B Macedo; Georges El-Hayek; Girish N Nadkarni; Sebastiano Gili; Mario Iannaccone; Ioannis Konstantinidis; John P Reilly

doi:10.1136/openhrt-2015-000248

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Interventional cardiology

Original research article

Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: an updated meta-analysis

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	Abstract	Full	Pdf
Jun 2015	20	1	10
Jul 2015	444	1185	483
Aug 2015	464	464	286
Sep 2015	853	261	271
Oct 2015	164	118	81
Nov 2015	145	112	113
Dec 2015	121	85	94
Jan 2016	236	101	299
Feb 2016	124	79	119
Mar 2016	145	103	130
Apr 2016	106	153	87
May 2016	101	86	55
Jun 2016	71	164	86
Jul 2016	70	135	60
Aug 2016	68	56	36
Sep 2016	60	78	35
Oct 2016	77	94	48
Nov 2016	139	151	56
Dec 2016	214	175	60
Jan 2017	50	63	53
Feb 2017	9	10	40
Mar 2017	14	127	69
Apr 2017	10	216	40
May 2017	5	321	61
Jun 2017	69	289	57
Jul 2017	272	258	59
Aug 2017	218	200	40
Sep 2017	136	124	38
Oct 2017	186	163	52
Nov 2017	191	173	29
Dec 2017	114	101	30
Jan 2018	128	122	80
Feb 2018	125	103	58
Mar 2018	188	156	65
Apr 2018	130	106	37
May 2018	141	123	12
Jun 2018	112	97	16
Jul 2018	109	93	45
Aug 2018	104	90	34
Sep 2018	141	131	24
Oct 2018	74	66	21
Nov 2018	114	92	20
Dec 2018	86	76	23
Jan 2019	89	61	23
Feb 2019	116	85	33
Mar 2019	91	73	28
Apr 2019	91	75	28
May 2019	69	59	18
Jun 2019	67	54	18
Jul 2019	54	51	12
Aug 2019	57	55	19
Sep 2019	62	58	18
Oct 2019	59	59	18
Nov 2019	53	51	10
Dec 2019	62	58	14
Jan 2020	72	71	19
Feb 2020	58	54	17
Mar 2020	88	86	14
Apr 2020	118	113	22
May 2020	62	61	15
Jun 2020	66	65	18
Jul 2020	75	60	11
Aug 2020	102	74	21
Sep 2020	75	65	23
Oct 2020	57	53	12
Nov 2020	45	39	12
Dec 2020	65	57	17
Jan 2021	69	52	23
Feb 2021	73	64	27
Mar 2021	141	108	31
Apr 2021	67	50	17
May 2021	76	74	45
Jun 2021	55	55	31
Jul 2021	111	109	30
Aug 2021	112	111	26
Sep 2021	77	75	36
Oct 2021	108	99	45
Nov 2021	51	45	21
Dec 2021	68	63	21
Jan 2022	57	50	26
Feb 2022	79	62	31
Mar 2022	125	98	41
Apr 2022	161	148	28
May 2022	115	91	33
Jun 2022	76	73	19
Jul 2022	69	66	33
Aug 2022	113	78	37
Sep 2022	114	111	45
Oct 2022	70	72	32
Nov 2022	92	74	34
Dec 2022	108	63	28
Jan 2023	117	81	32
Feb 2023	133	96	22
Mar 2023	110	78	51
Apr 2023	125	105	41
May 2023	83	61	30
Jun 2023	56	40	20
Jul 2023	77	62	30
Aug 2023	67	55	20
Sep 2023	71	63	41
Oct 2023	96	83	42
Nov 2023	107	91	19
Dec 2023	157	120	29
Jan 2024	54	57	19
Feb 2024	69	40	26
Mar 2024	119	90	48
Total	11729	11451	5062

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